Concordance of HER-2/Neu over Expression with Steroid Receptor Status in Female Breast Cancers
نویسندگان
چکیده
منابع مشابه
Relation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...
متن کاملEstrogen Receptor, Progesterone Receptor, and Her-2/neu Oncogene Expression in Breast Cancers Among Bangladeshi Women.
Two-thirds of all women who develop breast cancer each year live in Asia. In many countries, including Bangladesh, there are few data on the pathological characteristics of breast tumours. The objectives of this study were a) to describe the estrogen receptor (ER), progesterone receptor (PR), and the expression of Her-2/neu oncogene expression status in a large series of breast cancers occurrin...
متن کاملNuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers.
The prevalence and sites of expression of the c-erbB-4 receptor have been determined by immunocytochemical staining in a series of 178 human breast cancers. Most tumors displayed cytoplasmic staining of variable intensity. When compared with adjacent normal tissue, 32 cases (18%) showed lower than normal expression, and 13 (7%) showed greater than normal expression. Nuclear immunoreactivity, co...
متن کاملcorrelation of her2/neu over expression, p53 protein accumulation and steroid receptor status with tumor characteristics: an iranian study of breast cancer patients
background: molecular biomarkers are valuable in evaluation the course of malignancies. in this study, the relationship between her2/neu, p53, steroid receptors and clinicopathological features of patients with breast cancer has been assessed. methods : three hundred thirty nine women with a primary diagnosis of breast cancer from 2001 to 2006 were included. they were evaluated for tumor featu...
متن کاملExpression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.
A significant number of HER-2 amplified breast cancers is effectively treated by trastuzumab and further shows receptor-enhanced chemosensitivity. Recent studies have postulated transactivation of HER-2 also in tumors expressing phosphorylated/activated HER-2 (pHER-2) and of the HER-3/HER-4 ligand heregulin (HRG), independent of HER-2 amplification. As a consequence, a subset of tumors without ...
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ژورنال
عنوان ژورنال: Surgical Science
سال: 2014
ISSN: 2157-9407,2157-9415
DOI: 10.4236/ss.2014.58058